NON-INVASIVE PRENATAL DETERMINATION OF FETAL RHD GENOTYPING FROM MATERNAL PLASMA: A PRELIMINARY STUDY IN PAKISTAN
Authors: Nuruddin Mohammed, Fatima Kakal, Mehreen Somani and Wajiha Zafar
ABSTRACT
Objective: To determine the accuracy of the non-invasive pre-natal real-time polymerase chain reaction based fetal RhD genotyping from maternal plasma.
Study Design: Cross-sectional study.
Place and Duration of Study: Juma Health Sciences Research Laboratory, The Aga […]
ACCEPTANCE OF FIRST-TRIMESTER PRENATAL DIAGNOSIS FOR THE HAEMOGLOBINOPATHIES IN LEBANON
Author: L. Zahed
SUMMARY
We have interviewed 83 couples at risk for a haemoglobin disorder, mostly â-thalassaemia, in an effort to evaluate
their attitude towards first-trimester prenatal diagnosis. Most of the families had received poor education and were
of low socio-economic status and more […]
XMNI GG-POLYMORPHISM IN SIX UNRELATED PAKISTANI FAMILIES WITH INV/DEL GG(AGDB) DB-THALASSEMIA
Authors: Suhaib Ahmed1* and Masood Anwar2
1 Department of Pathology, PNS Shifa, Karachi, Pakistan
2 Department of Haematology, Armed Forces Institute of Pathology, Rawalpindi, Pakistan
The XmnI Gg-polymorphism (C–T polymorphism at position -158 to the Gg-globin gene)
was studied in 13 individuals from six […]
SPECTRUM OF BETA-THALASSEMIA MUTATIONS IN VARIOUS REGIONS OF PUNJAB AND ISLAMABAD, PAKISTAN: ESTABLISHMENT OF PRENATAL DIAGNOSIS
Authors: Shahid Mahmood Baig,* Ayesha Azhar,* Hammad Hassan
Abstract:
We present here an analysis of 888 unrelated beta-thal chromosomes consisting of 444 transfusion dependent children from various regions of Punjab and Islamabad Pakistan. By using Multiplex ARMS- PCR, restriction endonuclease analysis, allele specific oligonucleotide (ASO) hybridization and sequencing, 17 […]
ATTITUDES TO PRENATAL DIAGNOSIS AND TERMINATION OF PREGNANCY FOR 30 CONDITIONS AMONG WOMEN IN SAUDI ARABIA AND THE UK
Authors: Ayman Alsulaiman1, Jenny Hewison2, Khaled K. Abu-Amero3*, Shenaz Ahmed2, Josephine M. Green4 and Janet Hirst
ABSTRACT
Objective The aim of this research was to compare attitudes between women from different cultural and/or religious
backgrounds toward prenatal diagnosis (PND) and termination of pregnancy […]